Dose calculator

MOTS-c dose calculator

Convert any MOTS-c dose into syringe units in real time, pre-filled with a 10 mg / 2 mL example.

iPhone · Free to download

Last updated: May 13, 2026

Vial (mg)

Diluent (mL)

Dose (mg)

Dose unit

Draw on a U-100 syringe

100.0 units

Volume to draw

1.000 mL

MOTS-c is a peptide encoded inside the mitochondria that people inject for metabolic effects — energy, insulin sensitivity, and exercise capacity. It signals to muscle and fat tissue to use glucose and fat more efficiently, essentially mimicking some effects of exercise at the cellular level. Animal studies show clear improvements in insulin sensitivity and endurance; human data is early. This page covers reconstitution math and a typical 2–3-times-per-week logging cadence.

How the MOTS-c dose calculator works

MOTS-c doses are 5-10 mg, taken 3 times per week for mitochondrial-research protocols. On a 10 mg vial mixed with 2 mL water (5 mg/mL), a 5 mg dose draws 100 units — a full insulin syringe. Same large-dose pattern as Epithalon.

The formula is volume in mL equals dose mg divided by concentration mg/mL, then volume times one hundred to get units on a U-100 insulin syringe. With a 5 mg/mL MOTS-c solution and a 5 mg dose, the draw is 1.00 mL or about 100 units. Type any other dose and the unit count updates in real time — no spreadsheets, no guesswork.

Inputs that genuinely matter: concentration (which only changes when you reconstitute a new vial) and dose mass. Syringe type matters too, but only because U-100 vs U-40 changes the multiplier — almost every modern insulin syringe is U-100, which is why the math defaults to that. Edge cases worth flagging: switching from mcg to mg without checking the input unit, or carrying yesterday's unit count over to a new vial that was reconstituted with a different volume of BAC water.

Worked example

Walking one MOTS-c dose through the math

The vial holds 10 mg of MOTS-c, mixed into 2 mL of bacteriostatic water — concentration 5.00 mg/mL.
Your 5 mg dose ÷ 5.00 mg/mL = 1.000 mL of solution to pull.
Multiply by 100 (because U-100 means 100 units per mL): 1.000 × 100 = 100 units.
Double the dose to 10 mg and the unit count doubles to 200 — the relationship is linear at a fixed concentration.
Change the diluent volume and every one of these numbers moves; change the dose alone and only the last one does.

MOTS-c titration ladder at this concentration

What different MOTS-c dose steps draw on a U-100 insulin syringe at the example 5.00 mg/mL concentration.

Dose (mg)	Volume (mL)	Units (U-100)
2.5	0.500	50
5	1.000	100
10	2.000	200
20	4.000	400

Doubling the MOTS-c dose doubles the unit count. Halving it halves the count. Step-ups under 5 units are hard to read accurately — re-reconstitute with more water if your titration hits that range.

Scenarios people actually run into

Three things that come up logging MOTS-c

You're sitting at the 5 mg MOTS-c step and your prescriber bumps you up. The new dose is double — 200 units instead of 100. Same vial, same syringe, twice the volume on the line.
Your fingers reach for the syringe and the unit count from last week is still in your head. Half the time that number is fine; the other half, the vial changed and the right answer moved. The calculator is the second pair of eyes.
You skipped a week. MOTS-c cadence is 3 doses per week, and doubling up to "catch up" almost never reads how people expect — log the skip, then log the next normal dose.

Same-category neighbor

MOTS-c next to Epithalon

Both sit in the Other bucket — here's the dose math side by side on each one's example vial.

	MOTS-c	Epithalon
Example dose	5 mg	5 mg
Concentration	5.00 mg/mL	5.00 mg/mL
Units to draw	100	100

Want the full breakdown? Epithalon reference →

How MOTS-c dosing is tracked

Published research and user-documented protocols frequently describe an administration schedule of three times per week or on an every-other-day basis. This cadence is notably different from daily or weekly routines, introducing a significant variable for tracking adherence. The administration itself is typically documented as a subcutaneous injection, using a standard U-100 insulin syringe for measurement and delivery. Due to the relatively large dose size often studied, the choice of final concentration after reconstitution becomes an important practical consideration.

The timing of administration is another variable that individuals may choose to document in a personal log. Some experimental designs have explored the administration of MOTS-c in relation to physical activity, with the goal of studying its influence on exercise-induced metabolic adaptations. Others have examined its effects relative to fasting or fed states. Consequently, a detailed personal log might record not only the dose and date but also the time of day and its proximity to meals or exercise sessions to observe any patterns over time.

Published research protocols often use specific, fixed administration schedules, such as every-other-day dosing, to create a controlled environment. The goal in a formal study is to standardize all inputs to accurately observe the effects of a single variable. In contrast, a personal tracking plan documented on a platform serves the purpose of individual record-keeping and auditing. Users can plan and log their own schedule, which may be structured to mirror a research protocol or adjusted based on personal documentation goals.

Common MOTS-c dose-calculation mistakes

Calculating a unit dose based on a generic concentration instead of the specific concentration derived from their vial size and chosen diluent volume.
Reconstituting a 10 mg vial with 2 mL of water and being unprepared for the large 1 mL (100 unit) injection volume required for a 5 mg dose.
Committing calculation errors when converting between milligrams and micrograms, a frequent issue due to its higher milligram-level doses.

Frequently asked questions about MOTS-c dose calculator

How does the MOTS-c dose calculator turn mg into syringe units?

It runs two divisions in sequence. First it computes concentration (vial mg ÷ diluent mL) — for the example here that's 10 ÷ 2 = 5.00 mg/mL. Then it divides your dose by that concentration to get volume in mL, and multiplies by 100 to convert volume into U-100 syringe units. The output updates as you type so you can sanity-check before drawing. MOTS-c research focuses on mitochondrial markers — pair the dose log with relevant blood markers for pattern visibility.

Does the MOTS-c dose calculator know which syringe I'm using?

It assumes a U-100 insulin syringe — the most common type for sub-cutaneous peptide injections. U-100 means 100 units per mL. If you're using a U-40 syringe (rare outside veterinary contexts) the unit count is wrong by a factor of 2.5. Tuberculin syringes read in mL directly, so on those just use the volume figure. MOTS-c research focuses on mitochondrial markers — pair the dose log with relevant blood markers for pattern visibility.

Why does the same MOTS-c dose pull a different unit count today than last week?

Because either the vial or the diluent volume changed. Concentration depends on both. A 5 mg vial reconstituted with 1 mL is twice as concentrated as the same vial with 2 mL — same dose, half the units. Whenever you open a fresh vial, run the dose math again rather than carrying the prior count over. MOTS-c research focuses on mitochondrial markers — pair the dose log with relevant blood markers for pattern visibility.

What if my MOTS-c dose lands at fewer than 5 units?

That's the calculator telling you the current vial is too concentrated for the dose you want. Five units on a U-100 syringe is hard to read accurately — the markings get tight. Reconstitute the next vial with more bacteriostatic water (commonly 2 mL instead of 1 mL) so each dose covers a larger, cleaner volume. MOTS-c research focuses on mitochondrial markers — pair the dose log with relevant blood markers for pattern visibility.

Related on Peptide Pilot

Log every MOTS-c dose in the app

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