Dose calculator

Epithalon dose calculator

Convert any Epithalon dose into syringe units in real time, pre-filled with a 10 mg / 2 mL example.

iPhone · Free to download

Last updated: May 13, 2026

Vial (mg)

Diluent (mL)

Dose (mg)

Dose unit

Draw on a U-100 syringe

100.0 units

Volume to draw

1.000 mL

Epithalon is a short four-amino-acid peptide people use in cycles, usually for sleep quality and as a longevity-adjacent experiment. The interest comes from research suggesting it can lengthen telomeres — the protective caps on the ends of chromosomes — and influence the pineal gland's melatonin rhythm. The original Russian trials reported telomere-length increases and improved sleep markers, but independent replication is limited. This page covers reconstitution math and how people log a typical 10–20 day cycle.

How the Epithalon dose calculator works

Epithalon doses are 5-10 mg daily for 10-20 day cycles. On a 10 mg vial mixed with 2 mL water (5 mg/mL), a 5 mg dose draws 100 units — a full insulin syringe. Larger doses than most peptides, which makes the math straightforward.

The formula is volume in mL equals dose mg divided by concentration mg/mL, then volume times one hundred to get units on a U-100 insulin syringe. With a 5 mg/mL Epithalon solution and a 5 mg dose, the draw is 1.00 mL or about 100 units. Type any other dose and the unit count updates in real time — no spreadsheets, no guesswork.

Inputs that genuinely matter: concentration (which only changes when you reconstitute a new vial) and dose mass. Syringe type matters too, but only because U-100 vs U-40 changes the multiplier — almost every modern insulin syringe is U-100, which is why the math defaults to that. Edge cases worth flagging: switching from mcg to mg without checking the input unit, or carrying yesterday's unit count over to a new vial that was reconstituted with a different volume of BAC water.

Worked example

Walking one Epithalon dose through the math

The vial holds 10 mg of Epithalon, mixed into 2 mL of bacteriostatic water — concentration 5.00 mg/mL.
Your 5 mg dose ÷ 5.00 mg/mL = 1.000 mL of solution to pull.
Multiply by 100 (because U-100 means 100 units per mL): 1.000 × 100 = 100 units.
Double the dose to 10 mg and the unit count doubles to 200 — the relationship is linear at a fixed concentration.
Change the diluent volume and every one of these numbers moves; change the dose alone and only the last one does.

Epithalon titration ladder at this concentration

What different Epithalon dose steps draw on a U-100 insulin syringe at the example 5.00 mg/mL concentration.

Dose (mg)	Volume (mL)	Units (U-100)
2.5	0.500	50
5	1.000	100
10	2.000	200
20	4.000	400

Doubling the Epithalon dose doubles the unit count. Halving it halves the count. Step-ups under 5 units are hard to read accurately — re-reconstitute with more water if your titration hits that range.

Scenarios people actually run into

Three things that come up logging Epithalon

You're sitting at the 5 mg Epithalon step and your prescriber bumps you up. The new dose is double — 200 units instead of 100. Same vial, same syringe, twice the volume on the line.
Your fingers reach for the syringe and the unit count from last week is still in your head. Half the time that number is fine; the other half, the vial changed and the right answer moved. The calculator is the second pair of eyes.
You skipped a week. Epithalon cadence is 7 doses per week, and doubling up to "catch up" almost never reads how people expect — log the skip, then log the next normal dose.

Same-category neighbor

Epithalon next to NAD+

Both sit in the Other bucket — here's the dose math side by side on each one's example vial.

	Epithalon	NAD+
Example dose	5 mg	50 mg
Concentration	5.00 mg/mL	20.00 mg/mL
Units to draw	100	250

Want the full breakdown? NAD+ reference →

How Epithalon dosing is tracked

The administration schedules documented in Epithalon research are notably different from those of many other peptides, underscoring its unique biological context. A commonly observed protocol involves short-term, consecutive-day administration cycles lasting from 10 to 20 days. Following this intensive period, an extended break of several weeks to six months is typically observed before the cycle might be repeated. This cyclical cadence, sometimes performed one to four times per year, is a defining characteristic of the research initiated by the St. Petersburg Institute and is a critical variable to document for long-term analysis.

Due to the peptide's studied influence on circadian rhythms and melatonin pathways, administration timing is a carefully considered parameter in many research designs. Dosing is often scheduled for a consistent time each day, frequently in the late afternoon or evening, to align with the body's natural dip in cortisol and rise in melatonin. When considering a typical example dose of 5 mg, the mathematics of reconstitution require careful planning, as this can result in a large injection volume that fills or exceeds the capacity of certain types of syringes, influencing the choice of diluent volume from the outset.

The cyclical nature of the published Epithalon protocols also has implications for how the calendar around the cycle is documented, not just the cycle itself. A 10-to-20-day administration window followed by months of no administration produces a sparse log that can be hard to interpret in retrospect unless the off-period is annotated with the same care as the on-period. Researchers who handle the off-period as part of the dataset typically record sleep quality, perceived recovery, and any subjective changes during the break, which provides a baseline against which the next cycle's observations can be compared. Without that baseline, a year-over-year comparison of cycles collapses into a list of dose dates with no surrounding context, and the long inter-cycle gaps that define this peptide's protocol structure become a weakness of the record rather than a feature of it.

Common Epithalon dose-calculation mistakes

Reconstituting a 10 mg vial with 2 mL of diluent and not anticipating that a 5 mg dose requires drawing the full 100-unit capacity of a 1 mL syringe.
Continuing administration daily for months without interruption, a practice that deviates significantly from the cyclical 10-20 day protocols detailed in research literature.

Frequently asked questions about Epithalon dose calculator

How does the Epithalon dose calculator turn mg into syringe units?

It runs two divisions in sequence. First it computes concentration (vial mg ÷ diluent mL) — for the example here that's 10 ÷ 2 = 5.00 mg/mL. Then it divides your dose by that concentration to get volume in mL, and multiplies by 100 to convert volume into U-100 syringe units. The output updates as you type so you can sanity-check before drawing. Epithalon (Epitalon) is typically run in short cycles (10-20 days) once or twice per year, not continuously.

Does the Epithalon dose calculator know which syringe I'm using?

It assumes a U-100 insulin syringe — the most common type for sub-cutaneous peptide injections. U-100 means 100 units per mL. If you're using a U-40 syringe (rare outside veterinary contexts) the unit count is wrong by a factor of 2.5. Tuberculin syringes read in mL directly, so on those just use the volume figure. Epithalon (Epitalon) is typically run in short cycles (10-20 days) once or twice per year, not continuously.

Why does the same Epithalon dose pull a different unit count today than last week?

Because either the vial or the diluent volume changed. Concentration depends on both. A 5 mg vial reconstituted with 1 mL is twice as concentrated as the same vial with 2 mL — same dose, half the units. Whenever you open a fresh vial, run the dose math again rather than carrying the prior count over. Epithalon (Epitalon) is typically run in short cycles (10-20 days) once or twice per year, not continuously.

What if my Epithalon dose lands at fewer than 5 units?

That's the calculator telling you the current vial is too concentrated for the dose you want. Five units on a U-100 syringe is hard to read accurately — the markings get tight. Reconstitute the next vial with more bacteriostatic water (commonly 2 mL instead of 1 mL) so each dose covers a larger, cleaner volume. Epithalon (Epitalon) is typically run in short cycles (10-20 days) once or twice per year, not continuously.

Related on Peptide Pilot

Log every Epithalon dose in the app

iPhone · Free · No credit card