Dose calculator

Tesamorelin dose calculator

Convert any Tesamorelin dose into syringe units in real time, pre-filled with a 5 mg / 2 mL example.

iPhone · Free to download

Last updated: May 13, 2026

Vial (mg)

Diluent (mL)

Dose (mg)

Dose unit

Draw on a U-100 syringe

40.0 units

Volume to draw

0.400 mL

Tesamorelin is a daily injection people use specifically to reduce stubborn deep belly fat (visceral adipose tissue). It's an analog of growth hormone-releasing hormone (GHRH) that prompts the pituitary to release more of the body's own GH. In FDA trials for HIV-related lipodystrophy, daily 2 mg injections reduced visceral fat by about 15–18% over 26 weeks. This page covers reconstitution math and daily dose logging.

How the Tesamorelin dose calculator works

Tesamorelin is dosed daily at 1-2 mg. On a 5 mg vial mixed with 2 mL water (2.5 mg/mL), a 1 mg dose draws 40 units. The mg-scale doses make it different from most other GH secretagogues — the unit counts are larger and the vials empty faster.

The formula is volume in mL equals dose mg divided by concentration mg/mL, then volume times one hundred to get units on a U-100 insulin syringe. With a 2.5 mg/mL Tesamorelin solution and a 1 mg dose, the draw is 0.40 mL or about 40 units. Type any other dose and the unit count updates in real time — no spreadsheets, no guesswork.

Inputs that genuinely matter: concentration (which only changes when you reconstitute a new vial) and dose mass. Syringe type matters too, but only because U-100 vs U-40 changes the multiplier — almost every modern insulin syringe is U-100, which is why the math defaults to that. Edge cases worth flagging: switching from mcg to mg without checking the input unit, or carrying yesterday's unit count over to a new vial that was reconstituted with a different volume of BAC water.

Worked example

Walking one Tesamorelin dose through the math

The vial holds 5 mg of Tesamorelin, mixed into 2 mL of bacteriostatic water — concentration 2.50 mg/mL.
Your 1 mg dose ÷ 2.50 mg/mL = 0.400 mL of solution to pull.
Multiply by 100 (because U-100 means 100 units per mL): 0.400 × 100 = 40 units.
Double the dose to 2 mg and the unit count doubles to 80 — the relationship is linear at a fixed concentration.
Change the diluent volume and every one of these numbers moves; change the dose alone and only the last one does.

Tesamorelin titration ladder at this concentration

What different Tesamorelin dose steps draw on a U-100 insulin syringe at the example 2.50 mg/mL concentration.

Dose (mg)	Volume (mL)	Units (U-100)
0.5	0.200	20
1	0.400	40
2	0.800	80
4	1.600	160

Doubling the Tesamorelin dose doubles the unit count. Halving it halves the count. Step-ups under 5 units are hard to read accurately — re-reconstitute with more water if your titration hits that range.

Scenarios people actually run into

Three things that come up logging Tesamorelin

You're sitting at the 1 mg Tesamorelin step and your prescriber bumps you up. The new dose is double — 80 units instead of 40. Same vial, same syringe, twice the volume on the line.
Your fingers reach for the syringe and the unit count from last week is still in your head. Half the time that number is fine; the other half, the vial changed and the right answer moved. The calculator is the second pair of eyes.
You skipped a week. Tesamorelin cadence is 7 doses per week, and doubling up to "catch up" almost never reads how people expect — log the skip, then log the next normal dose.

Same-category neighbor

Tesamorelin next to GHRP-6

Both sit in the GH Secretagogue bucket — here's the dose math side by side on each one's example vial.

	Tesamorelin	GHRP-6
Example dose	1 mg	0.1 mg
Concentration	2.50 mg/mL	2.50 mg/mL
Units to draw	40	4

Want the full breakdown? GHRP-6 reference →

How Tesamorelin dosing is tracked

Protocols documented in published research on Tesamorelin typically involve a daily administration cadence, scheduled for seven days per week. The studied dose is substantial, frequently specified at 1 mg or 2 mg per day, which requires a much larger injection volume compared to GHRH fragments dosed in micrograms. For a 1 mg dose, drawing from a moderately concentrated vial requires careful measurement, often with a standard 1 mL U-100 insulin syringe to ensure accuracy for volumes that can be 40 units or more.

In a departure from the common evening schedule for many GH secretagogues, clinical trials for Tesamorelin predominantly utilized a morning-dosing schedule. The rationale is linked directly to its extended half-life; since the peptide provides a sustained GHRH signal, it is not necessary to time its administration to coincide with the primary natural growth hormone pulse during sleep. This morning administration pattern is a well-documented characteristic of the protocols established during its clinical development for its approved indication.

The structural stability of tesamorelin directly informs the administration schedules observed in research literature. Its resistance to DPP-IV degradation permits a daily dosing cadence, which allows for sustained engagement of the GHRH receptor. This contrasts sharply with native GHRH, which would require much more frequent administration to achieve a similar exposure profile. When planning documentation for a research project, this daily cadence is a key parameter to schedule and record. For calculation purposes, a 5 mg vial reconstituted with 2 mL of diluent contains 2.5 mg per mL. A 1 mg illustrative dose is therefore calculated as 0.4 mL or 40 units on a standard U-100 insulin syringe, often documented on a daily cadence.

Common Tesamorelin dose-calculation mistakes

Assuming the per-dose volume and syringe draw will be as small as sermorelin's and failing to plan for a larger subcutaneous injection.
Mistaking the typical milligram (mg) dose for micrograms (mcg) in the calculator, leading to a thousand-fold dosing error.
Attempting to reconstitute a 5 mg vial with an excessively small diluent volume, making the large 1 mg dose difficult to measure and draw accurately.

Frequently asked questions about Tesamorelin dose calculator

How does the Tesamorelin dose calculator turn mg into syringe units?

It runs two divisions in sequence. First it computes concentration (vial mg ÷ diluent mL) — for the example here that's 5 ÷ 2 = 2.50 mg/mL. Then it divides your dose by that concentration to get volume in mL, and multiplies by 100 to convert volume into U-100 syringe units. The output updates as you type so you can sanity-check before drawing. Tesamorelin clinical data (visceral fat reduction in HIV-associated lipodystrophy) used the 2 mg daily step.

Does the Tesamorelin dose calculator know which syringe I'm using?

It assumes a U-100 insulin syringe — the most common type for sub-cutaneous peptide injections. U-100 means 100 units per mL. If you're using a U-40 syringe (rare outside veterinary contexts) the unit count is wrong by a factor of 2.5. Tuberculin syringes read in mL directly, so on those just use the volume figure. Tesamorelin clinical data (visceral fat reduction in HIV-associated lipodystrophy) used the 2 mg daily step.

Why does the same Tesamorelin dose pull a different unit count today than last week?

Because either the vial or the diluent volume changed. Concentration depends on both. A 5 mg vial reconstituted with 1 mL is twice as concentrated as the same vial with 2 mL — same dose, half the units. Whenever you open a fresh vial, run the dose math again rather than carrying the prior count over. Tesamorelin clinical data (visceral fat reduction in HIV-associated lipodystrophy) used the 2 mg daily step.

What if my Tesamorelin dose lands at fewer than 5 units?

That's the calculator telling you the current vial is too concentrated for the dose you want. Five units on a U-100 syringe is hard to read accurately — the markings get tight. Reconstitute the next vial with more bacteriostatic water (commonly 2 mL instead of 1 mL) so each dose covers a larger, cleaner volume. Tesamorelin clinical data (visceral fat reduction in HIV-associated lipodystrophy) used the 2 mg daily step.

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