Dose calculator

Sermorelin dose calculator

Convert any Sermorelin dose into syringe units in real time, pre-filled with a 5 mg / 2 mL example.

iPhone · Free to download

Last updated: May 13, 2026

Vial (mg)

Diluent (mL)

Dose (mcg)

Dose unit

Draw on a U-100 syringe

0.01 units

Volume to draw

0.000 mL

Sermorelin is a daily evening injection people use to bump up their own natural growth hormone production, usually for sleep quality, recovery, and skin and body-composition changes. It's a shortened version of the body's GHRH signal, so it nudges the pituitary instead of replacing GH from outside. Clinical studies in adults show modest but measurable IGF-1 increases over months of nightly use. This page covers reconstitution math and nightly logging cadence.

How the Sermorelin dose calculator works

Sermorelin doses sit in the 100-300 mcg range, taken once at bedtime to align with natural GH pulse. On a 5 mg vial mixed with 2 mL water (2.5 mg/mL), a 200 mcg dose draws 8 units. Small draw, easy to repeat.

The formula is volume in mL equals dose mg divided by concentration mg/mL, then volume times one hundred to get units on a U-100 insulin syringe. With a 2.5 mg/mL Sermorelin solution and a 0.2 mg dose, the draw is 0.08 mL or about 8 units. Type any other dose and the unit count updates in real time — no spreadsheets, no guesswork.

Inputs that genuinely matter: concentration (which only changes when you reconstitute a new vial) and dose mass. Syringe type matters too, but only because U-100 vs U-40 changes the multiplier — almost every modern insulin syringe is U-100, which is why the math defaults to that. Edge cases worth flagging: switching from mcg to mg without checking the input unit, or carrying yesterday's unit count over to a new vial that was reconstituted with a different volume of BAC water.

Worked example

Walking one Sermorelin dose through the math

The vial holds 5 mg of Sermorelin, mixed into 2 mL of bacteriostatic water — concentration 2.50 mg/mL.
Your 0.2 mg dose ÷ 2.50 mg/mL = 0.080 mL of solution to pull.
Multiply by 100 (because U-100 means 100 units per mL): 0.080 × 100 = 8 units.
Double the dose to 0.4 mg and the unit count doubles to 16 — the relationship is linear at a fixed concentration.
Change the diluent volume and every one of these numbers moves; change the dose alone and only the last one does.

Sermorelin titration ladder at this concentration

What different Sermorelin dose steps draw on a U-100 insulin syringe at the example 2.50 mg/mL concentration.

Dose (mg)	Volume (mL)	Units (U-100)
0.1	0.040	4
0.2	0.080	8
0.4	0.160	16
0.8	0.320	32

Doubling the Sermorelin dose doubles the unit count. Halving it halves the count. Step-ups under 5 units are hard to read accurately — re-reconstitute with more water if your titration hits that range.

Scenarios people actually run into

Three things that come up logging Sermorelin

You're sitting at the 0.2 mg Sermorelin step and your prescriber bumps you up. The new dose is double — 16 units instead of 8. Same vial, same syringe, twice the volume on the line.
Your fingers reach for the syringe and the unit count from last week is still in your head. Half the time that number is fine; the other half, the vial changed and the right answer moved. The calculator is the second pair of eyes.
You skipped a week. Sermorelin cadence is 7 doses per week, and doubling up to "catch up" almost never reads how people expect — log the skip, then log the next normal dose.

Same-category neighbor

Sermorelin next to Ipamorelin

Both sit in the GH Secretagogue bucket — here's the dose math side by side on each one's example vial.

	Sermorelin	Ipamorelin
Example dose	0.2 mg	0.2 mg
Concentration	2.50 mg/mL	1.00 mg/mL
Units to draw	8	20

Want the full breakdown? Ipamorelin reference →

How Sermorelin dosing is tracked

Research protocols for Sermorelin are built around its very short half-life and the body's natural circadian rhythm of GH secretion. Administration is frequently scheduled as a single subcutaneous injection per day, timed shortly before bedtime. This approach is intended to have the peptide's activity coincide with the largest natural GH pulse of the day, which occurs during the first few hours of slow-wave sleep. The goal is to augment this existing nocturnal pulse rather than to create an independent secretory event at another time.

A U-100 insulin syringe is the instrument typically used for subcutaneous administration, with the cadence in example protocols often set at seven times per week for consistency. The choice of a pre-sleep injection time is a deliberate strategy to align the peptide's stimulus with the body's endogenous endocrine schedule. The entire protocol structure is designed around Sermorelin's identity as a short-acting GHRH mimetic, leveraging its rapid onset and clearance to work in concert with natural pituitary function.

Protocols detailed in published literature frequently document a specific administration cadence tied to the sleep cycle. A common approach studied involves a single daily administration scheduled immediately before bedtime. This timing is methodically chosen to coincide with the body's primary endogenous GH pulse, which occurs during the first few hours of deep sleep. For personal data tracking purposes, documenting the precise time of administration relative to sleep onset is a critical variable to record. For instance, an individual following a daily cadence might calculate a 200 mcg illustrative dose from a 5 mg vial reconstituted with 2 mL, which involves drawing 0.08 mL or 8 units on a U-100 syringe.

Common Sermorelin dose-calculation mistakes

Using a very low diluent volume, such as 0.5 mL, which makes the accurate measurement of a typical 200 mcg dose exceedingly difficult on a U-100 syringe.
Mistaking its short half-life for a lack of activity and consequently attempting to use multi-day dosing intervals.
Dosing in the morning, which works against the body's natural GH circadian rhythm and the peptide's designed function.

Frequently asked questions about Sermorelin dose calculator

How does the Sermorelin dose calculator turn mg into syringe units?

It runs two divisions in sequence. First it computes concentration (vial mg ÷ diluent mL) — for the example here that's 5 ÷ 2 = 2.50 mg/mL. Then it divides your dose by that concentration to get volume in mL, and multiplies by 100 to convert volume into U-100 syringe units. The output updates as you type so you can sanity-check before drawing. Sermorelin is most often dosed once at bedtime to align with natural GH release — split-dose protocols are uncommon.

Does the Sermorelin dose calculator know which syringe I'm using?

It assumes a U-100 insulin syringe — the most common type for sub-cutaneous peptide injections. U-100 means 100 units per mL. If you're using a U-40 syringe (rare outside veterinary contexts) the unit count is wrong by a factor of 2.5. Tuberculin syringes read in mL directly, so on those just use the volume figure. Sermorelin is most often dosed once at bedtime to align with natural GH release — split-dose protocols are uncommon.

Why does the same Sermorelin dose pull a different unit count today than last week?

Because either the vial or the diluent volume changed. Concentration depends on both. A 5 mg vial reconstituted with 1 mL is twice as concentrated as the same vial with 2 mL — same dose, half the units. Whenever you open a fresh vial, run the dose math again rather than carrying the prior count over. Sermorelin is most often dosed once at bedtime to align with natural GH release — split-dose protocols are uncommon.

What if my Sermorelin dose lands at fewer than 5 units?

That's the calculator telling you the current vial is too concentrated for the dose you want. Five units on a U-100 syringe is hard to read accurately — the markings get tight. Reconstitute the next vial with more bacteriostatic water (commonly 2 mL instead of 1 mL) so each dose covers a larger, cleaner volume. Sermorelin is most often dosed once at bedtime to align with natural GH release — split-dose protocols are uncommon.

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