Comparison

Mod GRF 1-29 vs CJC-1295

Mod GRF 1-29 (CJC-1295 without DAC) next to long-acting CJC-1295 with DAC — same backbone, very different half-life and dosing cadence.

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Last updated: May 6, 2026

Field

Mod GRF 1-29

CJC-1295

Where Mod GRF 1-29 and CJC-1295 actually diverge

	Mod GRF 1-29	CJC-1295
Cadence	21/wk	7/wk
Concentration on example	1.00 mg/mL	1.00 mg/mL
Math weeks per vial	1.0	2.9
Category	GH	GH Secretagogue

Bolded values are the higher of the two on numeric rows. Same-value rows aren't a verdict — they're shared properties.

Mod GRF 1-29 vs CJC-1295: the actual decision

These two molecules share the same backbone — both are 30-amino-acid modified GHRH(1-29) analogs — and the difference is whether the molecule is conjugated to a Drug Affinity Complex (DAC) that binds it to serum albumin and dramatically extends its half-life. Mod GRF 1-29 is the no-DAC version with a half-life measured in minutes; CJC-1295 in its commonly-discussed form includes the DAC and has a half-life measured in days. Same molecule, completely different cadence.

Pulse versus tonic exposure is the structural consequence. Mod GRF 1-29 produces a sharp, short GH pulse that resembles the body's natural overnight pattern — typically administered pre-bed in the published protocols, often paired with a GHRP for a coordinated pulse from both sides of the pathway. CJC-1295 with DAC produces sustained GH elevation rather than a discrete pulse, which is the trade-off the DAC modification was designed for. Researchers who prioritize preserving pulsatility tend to log Mod GRF; researchers who prioritize convenience and cumulative exposure tend to log CJC-1295.

Mechanism, cadence, and what shows up in a log

Cadence is the most-tracked difference in side-by-side logs. Mod GRF 1-29 protocols are written around once-or-twice-daily administration; CJC-1295 with DAC protocols sit at twice-weekly or even weekly. A 5 mg vial of Mod GRF dosed daily empties in roughly the same calendar window that a 5 mg vial of CJC-1295 with DAC stretches across months — the vial-duration calculator linked below shows the gap at your own example vials.

Reconstitution is identical between the two molecules and the unit math on a 100-unit syringe is in the same range at typical vial sizes. The mg-to-units calculator linked below handles either once vial concentration is set. The most common confusion in research-peptide logs is which version is in the vial when the label just reads CJC-1295 — the DAC-versus-no-DAC distinction is the entire reason the cadence question has two right answers depending on which molecule you actually have.

Mod GRF 1-29 vs CJC-1295: the numbers, side by side

Start with what actually goes into a syringe. The example Mod GRF 1-29 vial on this site reconstitutes 2 mg in 2 mL of bacteriostatic water — about 1.00 mg per mL, which yields roughly 20 doses at the 0.1 mg example and lasts about 1.0 weeks at 21 doses per week. The example CJC-1295 vial reconstitutes 2 mg in 2 mL (1.00 mg/mL), which yields about 20 doses at 100 mcg and stretches roughly 2.9 weeks at 7 doses per week. Those numbers are the starting point most people forget to write down, and they decide everything downstream — refill timing, unit count on the syringe barrel, and whether a 30-mL bac-water bottle stretches across one vial or two.

Category context matters too. Mod GRF 1-29 is a GH molecule; CJC-1295 is a GH Secretagogue molecule. People comparing them are usually deciding between two different mechanisms aimed at overlapping goals, which is a more structural choice than two molecules in the same family — the side-by-side table above puts the vial math in the same units so the comparison is direct. Cadence helps frame the rest: Mod GRF 1-29 is logged about 21× per week in the example schedule, CJC-1295 about 7×.

The single most-asked-about mistake on each page is worth surfacing here, because they rarely overlap. On the Mod GRF 1-29 side: Using the peptide without being on an empty stomach, which can blunt the growth hormone release. On the CJC-1295 side: Applying a daily dosing frequency appropriate for the no-DAC variant to the long-acting DAC variant. Both are the kind of thing a tracked log catches early and an untracked routine catches late.

Frequently asked questions about Mod GRF 1-29 vs CJC-1295

What's the difference between Mod GRF 1-29 and CJC-1295 with DAC?

Why do people stack Mod GRF 1-29 with Ipamorelin?

People use these two together to create a stronger GH pulse. Mod GRF 1-29 and Ipamorelin work on two different receptors in the pituitary gland. Stimulating both pathways at once results in a synergistic effect, causing a much larger release of growth hormone than either peptide could on its own.

How should I time my Mod GRF 1-29 doses?

Users often time their doses 1-3 times per day to support the body's natural GH rhythms. Common times are upon waking, after a workout, or before bed. It's also important to inject on an empty stomach, as high blood sugar from carbohydrates or fats can reduce the amount of GH that gets released.

What is the functional difference between CJC-1295 with DAC and without DAC?

Why is CJC-1295 without DAC frequently paired with ipamorelin in research?

This combination creates a synergistic effect by stimulating the pituitary gland through two separate pathways. CJC-1295 without DAC is a GHRH analog that stimulates the GHRH receptor, while ipamorelin is a ghrelin mimetic that stimulates the ghrelin receptor (GHSR). Activating both receptors at once results in a much larger release of growth hormone than stimulating either one alone.

For a 2 mg vial reconstituted with 2 mL of water, how many units is a 100 mcg dose?

Reconstituting a 2 mg (2,000 mcg) vial with 2 mL of fluid yields a concentration of 1,000 mcg per mL. A 100 mcg dose is therefore equal to 0.1 mL of this solution. On a standard U-100 insulin syringe, 0.1 mL measures as exactly 10 units.

Related on Peptide Pilot

Log Mod GRF 1-29 and CJC-1295 side by side in the app

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